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These results are consistent with prior studies showing that statins inhibit selenoprotein synthesis and statin-induced cell death has features of ferroptosis and may be rescued by ferroptosis inhibitors although this is universally consistent for all statins [11, 45–47]

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What’s concerning is how closely it’s tied to modern lifestyles: • Prolonged sitting • Work-from-home routines • Long flights • Limited physical movement Early signs are often subtle: • Leg swelling • Heaviness • Warmth (even without pain) Ignoring these symptoms can lead to serious complications, including life-threatening conditions